Measurement of gastric emptying during and between meal intake in free-feeding Lewis rats.

نویسندگان

  • P van der Velde
  • I Koslowsky
  • H S Koopmans
چکیده

A new scintigraphic measurement technique is described that allows accurate assessment of gastric emptying in between as well as during a number of successive meals. Measurements were made every minute of food intake, gastric nutrient filling, and gastric emptying over a 6 h, 40 min period in conscious, free-feeding, loosely restrained rats. Before receiving access to the food, the animals had been deprived for a period of 31 h. Over the full duration of the experiment, an average rate of gastric emptying of 2.46 ± 0.18 (SE) kcal/h was established. During most meals, however, the gastric emptying rate was increased so that an average of 26.9 ± 2.7% of the ingested calories was emptied while the animals were feeding, with an average emptying rate of 0.15 ± 0.014 kcal/min or 8.88 ± 0.84 kcal/h. This transient increase in the rate of gastric emptying was followed by a subsequent slowing of gastric emptying after meal termination; in the 10-min postmeal interval, an average emptying rate of 0.96 ± 0.12 kcal/h was found. Despite these fluctuations during and immediately after meals, a relatively constant rate of caloric emptying is maintained over longer periods. There were no differences between the emptying rate during the first meal when the gastrointestinal tract was still empty, compared with later meals when the gastrointestinal tract had been filled with food. The emptying rate during the 10-min postmeal interval, however, was significantly reduced during later meals. The results suggest that gastric emptying is controlled by different mechanisms during and after the ingestion of food and that these mechanisms remain in effect at various degrees of gastrointestinal filling.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Measurement of gastric emptying during and between meal intake in free-feeding Lewis rats

Van der Velde, P., I. Koslowsky, and H. S. Koopmans. Measurement of gastric emptying during and between meal intake in free-feeding Lewis rats. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R597–R605, 1999.—A new scintigraphic measurement technique is described that allows accurate assessment of gastric emptying in between as well as during a number of successive meals. Measur...

متن کامل

NMDA receptor participation in control of food intake by the stomach.

We previously reported that MK-801 (dizocilpine), an antagonist of N-methyl-D-aspartate (NMDA)-type glutamate receptors, increased meal size and duration in rats. MK-801 did not increase sham feeding or attenuate reduction of sham feeding by intraintestinal nutrient infusions. These results suggested that the MK-801-induced increase in meal size did not depend on antagonism of postgastric satie...

متن کامل

AREGU May 47/5

Covasa, Mihai, Robert C. Ritter, and GilbertA. Burns. NMDA receptor participation in control of food intake by the stomach. Am J Physiol Regulatory Integrative Comp Physiol 278: R1362–R1368, 2000.—We previously reported that MK801 (dizocilpine), an antagonist of N-methyl-D-aspartate (NMDA)-type glutamate receptors, increased meal size and duration in rats. MK-801 did not increase sham feeding o...

متن کامل

Specific adaptation of gastric emptying to diets with differing protein content in the rat: is endogenous cholecystokinin implicated?

BACKGROUND Recent studies indicate that gastric emptying may be influenced by patterns of previous nutrient intake. Endogenous cholecystokinin (CCK), whose synthesis and release can be affected by dietary intake, has a major role in the regulation of gastric emptying. AIMS To evaluate the influence of diets with differing protein content on gastric emptying of differing liquid test meals and ...

متن کامل

Specific adaptation of gastric emptying to diets with diVering protein content in the rat: is endogenous cholecystokinin implicated?

Background—Recent studies indicate that gastric emptying may be influenced by patterns of previous nutrient intake. Endogenous cholecystokinin (CCK), whose synthesis and release can be aVected by dietary intake, has a major role in the regulation of gastric emptying. Aims—To evaluate the influence of diets with diVering protein content on gastric emptying of diVering liquid test meals and plasm...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The American journal of physiology

دوره 276 2 Pt 2  شماره 

صفحات  -

تاریخ انتشار 1999